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UNFPA, Partners, to Launch new Hellosmile Campaign to Help Prevent Cervical Cancer - 07 May 2012
UNITED NATIONS, New York&mdash;The Hellosmile Project, a joint campaign to prevent cervical cancer, initiated and led by TOKYO FM Broadcasting, and which includes UNFPA and other partners, will be officially launched in the United States this week. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Drug Before Surgery Clears Prostate Cancer
(MedPage Today) -- A third of men with localized, high-risk prostate cancer achieved pathologic complete response or near-complete response following neoadjuvant therapy with abiraterone and an LHRH agonist, results of a preliminary clinical study showed. (Source: MedPage Today Urology)
Markey Receives $6.25 Million to Study Deadly Blood and Bone Marrow Disease
The University of Kentucky Markey Cancer Center has received more than $6 million to study a deadly blood and bone marrow disease often caused by chemotherapy or radiation treatments. A $5 million grant from the Edward P. Evans Foundation, along with a $1.25 million donor gift, will fund research of myelodysplastic syndrome (MDS). At UK, principal investigator Gary Van Zant and co-principal investigators Subbarao Bondada and Daret St. Clair lead the three research labs funded. The Cincinnati lab will be led by Hartmut Geiger and the Arkansas lab will have two co-principal investigators, Martin Hauer-Jensen and Daohong Zhou. The three medical centers have collaborated on MDS research in the past. (Source: UK College of Medicine News)
Northwest Bio Provides Update On DCVax(R)-L Brain Cancer Trial
Amendment Accepted By FDA, Enhancing and Upgrading the Trial 41 US Clinical Trial Sites Now In Operation BETHESDA, Md., May 17, 2012 (HSMN NewsFeed) -- Northwest Biotherapeutics (NWBO.OB) (NW Bio) announced today that it now has 41 clinical trial s... Biopharmaceuticals, Oncology, FDANorthwest Biotherapeutics, DCVax, Glioblastoma (Source: HSMN NewsFeed)
Varian Medical Systems to Showcase Radiosurgery Technology for Non-invasive Treatment of Early Stage Inoperable Lung Cancer
SAN FRANCISCO, May 17, 2012 (HSMN NewsFeed) -- Varian Medical Systems (VAR) will showcase radiosurgery technologies for treating early-stage inoperable lung cancer and other conditions non-invasively at the 2012 International Conference of the American T... Devices, OncologyVarian Medical Systems, RapidArc, Radiosurgery, TrueBeam, radiotherapy (Source: HSMN NewsFeed)
BP Meds No Help Against Colorectal Cancer (CME/CE)
(MedPage Today) -- Long-term use of common beta blocker drugs to combat high blood pressure does not decrease the risk of developing colorectal cancer, a large population-based study found. (Source: MedPage Today Primary Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Well: Life, Interrupted: Hope Is My New Address
I've left the isolation of the hospital after my bone marrow transplant and no longer need to be connected to IVs around the clock. I'm enjoying my freedom, but cancer continues to dictate my choices, writes Suleika Jaouad. (Source: NYT)
EDAP to Showcase New Data at 2012 American Urological Association Annual Meeting
LYON, France, May 17, 2012 (GLOBE NEWSWIRE) -- EDAP TMS SA (Nasdaq:EDAP), a global leader in therapeutic ultrasound, announced today that its Ablatherm(r) High Intensity Focused Ultrasound (HIFU) will be featured in two presentations supporting the technology's efficacy for the treatment of localized prostate cancer, both as a primary care option and as a salvage treatment. The data, as well as EDAP's extracorporeal shock wave lithotripsy (ESWL) platform, the Sonolith(r) i-move, will be featured at the American Urological Association (AUA) 2012 Annual Meeting, held May 19-23 in Atlanta, GA. (Source: Medical News (via PRIMEZONE))
New M.D. Anderson breast cancer vaccine shows promise
Researchers at Houston-based M.D. Anderson Cancer Center reported promising results from an experimental new breast cancer vaccine. The vaccine, one of many now in testing, significantly decreased the recurrence rate of breast cancer in women who had been treated for a common tumor type, according to a study led by The University of Texas M.D. Anderson Cancer Center, the Houston Chronicle reports. The new vaccine triggers the patient's immunity against a tumor protein, known as HER2, present to... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
man has chest rebuilt with concrete after massive melon-sized tumour removed
Marek Barden was diagnosed with cancer in August 2011 after complaining of a lump. The church worker, from Bristol, had a 3.3lb tumour wrapped around his ribs. (Source: the Mail online | Health)
Agilent to buy cancer-diagnostic company Dako for $2.2B
Agilent Technologies Inc. said on Thursday that it has agreed to buy Danish cancer diagnostic test company Dako for $2.2 billion in cash. The Santa Clara-based test and measurement equipment company (NYSE:A) is buying Dako from private equity group EQT. The deal is expected to expand Agilent's clinical diagnostics offerings and close within 60 days. ?In the rapidly growing diagnostics market, Dako?s products and capabilities are a strategic complement to Agilent?s existing offerings,?... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
New genetic 'map' drawn up that will give better diagnosis for breast cancer patients and more effective treatment
Researchers at the Wellcome Trust Sanger Institute in Hinxton, Cambridgeshire, discovered that breast cancer is a diverse range of species rather than a single one. (Source: the Mail online | Health)
Task Force endorses limited skin cancer prevention counseling
Physicians should counsel individuals aged 10?24 years about the risk for developing skin cancer as a consequence of sun exposure, whereas older individuals may not benefit from such advice, the US Preventive Services Task Force suggests. (Source: MedWire News - Oncology)
Curis Announces Collaborators' Presentation of Erivedge(TM) and Debio 0932 Clinical Data at ASCO Annual Meeting
LEXINGTON, Mass., May 17, 2012 (GLOBE NEWSWIRE) -- Curis, Inc. (Nasdaq:CRIS), a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that several abstracts on its partnered programs have been accepted by the American Society of Clinical Oncology (ASCO) for presentation at its 2012 Annual Meeting being held from June 1-5 in Chicago, IL. (Source: Medical News (via PRIMEZONE))
Interaction between regulatory T cells and cancer stem cells
AbstractThe concept that cancer stem cells/tumor stem cells/cancer initiating cells (CSCs) are one of the key center to cure neoplastic disease has drawn an increasing attention recent years. Because of their high resistance and potential to initiate tumors, CSCs are considered a critical factor associated with tumor relapse. Regulatory T (Treg) cells, a group of immune cells with tumor?promoting effect, exert their function through inhibition of effector T cells and regulation of the tumor microenvironment by producing a series of soluble factors. However, the interactions between Tregs and CSCs are less understood. The mechanisms of how Tregs, as tumor?promoting cells, manipulate CSCs remain obscure. In this review, we elucidate their interactions. (Source: International Journal of C...
Correct diagnosis of warthin tumor in the parotid gland with dynamic MRI.
We examined two patients for this study. The first was a 53-year old male, heavy smoker, experiencing manic-depressive episodes. He received a brain MRI at which time his parotid tumor was discovered. Parotid FNAC indicated a squamous cell carcinoma. The second patient was a 76-year old male, moderate smoker and drinker, who had been complaining about swelling in the neck. FNAC of the parotid indicated acinic cell carcinoma and gadolinium-enhanced MRI suggested the tumor was malignant. Prior to surgically extracting of these masses, we performed dynamic MRI on each patient. Both tumors exhibited a pattern consisting of rapid enhancement and rapid attenuation, the pattern of which is characteristic of WT. The surgical specimens confirmed that both were WTs without malignant transformation. ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
NHS 'OK' for prostate cancer drug Zytiga
?NHS ban on pill to treat prostate cancer is lifted,? the Daily Express has said, while the Daily Mail has warned that a ?prostate cancer wonder drug? was set for approval ?south of border but turned down by Scotland?. The stories focus on the fact that the prostate cancer drug abiraterone may soon be available on the NHS in certain circumstances. These stories are based on a revised decision on draft guidance published by The National Institute for Health and Clinical Excellence (NICE), which makes recommendations about which treatments should be available on the NHS in England and Wales. It recommends that abiraterone (brand name Zytiga) be made available for the treatment of advanced prostate cancer that has not responded to chemotherapy. Previous draft NICE guidance publish...
Zytiga Eliminates Some High-Risk Prostate TumorsZytiga Eliminates Some High-Risk Prostate Tumors
Neoadjuvant therapy has never panned out in prostate cancer. But one looks good now. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Platinum Quantum Dots and Their Cytotoxic Effect Towards Myoblast Cancer Cells (C2C12)
(Source: Journal of Biomedical Nanotechnology)
Op-Ed Contributor: A Judge?s Plea for Medical Marijuana
For cancer patients, marijuana is a medical and a human rights issue. New York should pass the medical marijuana bill this year. (Source: NYT)
Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1
p90 ribosomal S6 kinases (RSKs) respond to various mitogen stimuli and comprise two distinct protein kinase domains. The C-terminal kinase domain (CTKD) receives signal from ERK1/2 and adopts an autoinhibitory mechanism. Here, the crystal structure of human RSK1 CTKD is reported at 2.7?Å resolution. The structure shows a standard kinase fold, with the catalytic residues in the ATP-binding cleft orientated in optimal conformations for phosphotransfer. The inactivation of the CTKD is conferred by an extra ?-helix (?L), which occupies the substrate-binding groove. In combination with previous knowledge, this structure indicates that activation of RSK1 involves the removal of ?L from the substrate-binding groove induced by ERK1/2 phosphorylation. (Source: Acta Crystallographica Section D...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Advanced Prostate Cancer Drug May Help at Earlier Stage
In study, one-third benefited from taking Zytiga plus hormone therapy for 6 months before surgery (Source: The Doctors Lounge - Endocrinology and Diabetes)
Many Primary Care Docs Don?t Know Long-Term Effects of Chemo: Survey
Experts stress that information needs to be passed on after cancer treatment ends (Source: The Doctors Lounge - Health News)
Does access to a colorectal cancer screening website and/or a nurse-managed telephone help line provided to patients by their family physician increase fecal occult blood test uptake?: A pragmatic cluster randomized controlled trial study protocol
DiscussionThe study intervention has the potential to increase patient fecal occult blood test uptake, decrease colorectal cancer mortality and morbidity, and improve the health of Manitobans. If utilization of the website and/or telephone support line result in clinically significant increases in colorectal cancer screening uptake, changes in screening at the policy- and system-level may be warranted. Trial Registration: clinicaltrials.gov identifier NCT01026753. (Source: BMC Cancer)
Validating the impact of a molecular subtype in ovarian cancer on outcomes: A study of the OVCAD Consortium
Most patients with epithelial ovarian cancer (EOC) are diagnosed at advanced stage and have a poor prognosis. However, a small proportion of these patients will survive, whereas others will die very quickly. Clinicopathological factors do not allow precise identification of these subgroups. Thus, we have validated a molecular subclassification as new prognostic factor in EOC. One hundred and ninety?four patients with Stage II?IV EOC were characterized by whole?genome expression profiling of tumor tissues and were classified using a published 112 gene set, derived from an International Federation of Gynecology and Obstetrics (FIGO) stage?directed supervised classification approach. The 194 tumor samples were classified into two subclasses comprising 95 (Subclass 1) and 99 (Subclass ...
Hedgehog inhibitor decreases chemosensitivity to 5?fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer
Pancreatic cancer is one of the deadliest types of cancer. Previously, we showed that hypoxia increases invasiveness through upregulation of Smoothened (Smo) transcription in pancreatic ductal adenocarcinoma (PDAC) cells. Here, we first evaluated whether hypoxia?induced increase in Smo contributes to the proliferation of PDAC cells. We showed that Smo, but not Gli1, inhibition decreases proliferation significantly under hypoxic conditions. To further investigate the effects of Smo on PDAC growth, cell cycle analysis was carried out. Inhibition of Smo under hypoxia led to G0/G1 arrest and decreased S phase. As 5?fluorouracil (5?FU) and gemcitabine, which are first?line drugs for pancreatic cancer, are sensitive to S phase, we then evaluated whether cyclopamine?induced decreased S ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
CTHRC1 is upregulated by promoter demethylation and transforming growth factor??1 and may be associated with metastasis in human gastric cancer
The gene, collagen triple helix repeat containing 1 (CTHRC1), has been reported to increase in several kinds of human solid cancers and is associated with tumor invasion and metastasis. To date, the expression and function of CTHRC1 in gastric cancer (GC) have not been reported. The aim of this study was to investigate the expression levels and regulatory transcription mechanisms of CTHRC1 in GC. Immunohistochemical analysis revealed that CTHRC1 expression was markedly increased in carcinoma compared with normal gastric mucosa, chronic atrophic gastritis, and intestinal metaplasia (P &lt; 0.05 for all), and this overexpression in tumor was related to depth of tumor invasion. Moreover, RNA interference?mediated knockdown and ectopic expression of CTHRC1 showed that CTHRC1 promoted tumor...
MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome
Conclusion:The unexpected contrasting correlation between HLA?A,B,C expression, and clinical outcome depending on HPV, indicates essential differences between HPV?positive and HPV?negative TSCC. Furthermore, our data demonstrate that for both HPV?positive and HPV?negative TSCC, the expression of HLA?A,B,C together with HPV may serve as a useful biomarker for predicting clinical outcome. (Source: International Journal of Cancer)
Insulinemia and the risk of breast cancer and its relapse
A fairly large body of evidence has shown that insulin is a tumour?promoting agent, especially for breast cancer. High circulating and microenvironmental levels of insulin may directly increase the risk of breast cancer via the activation of cognate receptors expressed on normal and cancer cells and indirectly be associated with other known metabolic risk factors of cancer that usually are present in conjunction with the hyperinsulinic state.The focus of this review is to analyse and discuss available data in the literature on the possible causative/prognostic role of insulin resistance/hyperinsulinemia in breast cancer development and progression. (Source: Diabetes, Obesity and Metabolism)
Existential issues among nurses in surgical care ? a hermeneutical study of critical incidents
Conclusion.? Findings are interpreted and discussed in the framework of Buber?s philosophy of the relationships I?Thou and I?It, emphasizing nurses? different relationships with patients during the process of caring. Some nurses integrate their personal self into caring whereas others do not. The most important finding and new knowledge are that some nurses felt insecure and were caught somewhere in between I?Thou and I?It. (Source: Journal of Advanced Nursing)
Neoplastic leptomeningitis presenting in a melanoma patient treated with dabrafenib (a V600EBRAF inhibitor): a case report.
Conclusion: Starting with a clinical case, we discuss the pathogenesis of leptomeningeal metastases and whether the leptomeninges may represent a sanctuary where melanoma cells may generate resistance and/or where BRAF inhibitors cannot reach an adequate concentration for significant activity. We assess whether treatment with BRAF inhibitors in melanoma patients should be interrupted as soon as disease progression appears or continued beyond progression through the administration of additional compounds. (Source: BioMed Central)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Computational identification and experimental validation of microRNAs binding to the Alzheimerrelated gene ADAM10
Conclusions: Our approach shows the requirement of incorporating specific, disease-associated selectioncriteria into the prediction process to reduce the amount of false positive predictions. Insummary, our method identified three miRNAs strongly suggested to be involved in AD,which possibly regulate ADAM10 expression and hence offer possibilities for thedevelopment of therapeutic treatments of AD. (Source: BioMed Central)
Depolarized MUC1 Expression Is Closely Associated With Hypoxic Markers and Poor Outcome in Resected Non-Small Cell Lung Cancer
MUC1 is transmembrane mucin aberrantly overexpressed in various cancers. However, little is known about how MUC1 expression is associated with hypoxia, glucose metabolism, and epidermal growth factor receptor (EGFR) pathway, which are related to cancer progression. The aim of this study is to evaluate the relationship between MUC1 expression and these molecular markers in lung cancer. Of all 126 patients, high-grade polarized expression (HP), low-grade polarized expression (LP), and depolarized expression (DP) group were 50 (39.7%), 35 (27.8%), and 41 (32.5%), respectively. Depolarized MUC1 expression was significantly associated with poor outcome and was closely correlated with glucose metabolism (Glut1), hypoxia (HIF-1&alpha;), angiogenesis (vascular endothelial growth factor and microve...
Significance of the Correlation Between the Expression of Interleukin 6 and Clinical Features in Patients With Non-Small Cell Lung Cancer
Conclusions. The expression of IL-6 in tumor correlated with the concentration of serum IL-6, tumor progression, and overall survival in patients with NSCLC. (Source: International Journal of Surgical Pathology)
Adenohibernoma: A Rare Breast Tumor
This study reports the third case of adenohibernoma of the breast, which is not accompanied by breast cancer differing from the previous cases. And, to the best of the authors&rsquo; knowledge, this is also the first case of adenohibernoma of the breast that has demonstrated adipophilin expression immunohistochemically. (Source: International Journal of Surgical Pathology)
UNFPA, Partners, to Launch new Hellosmile Campaign to Help Prevent Cervical Cancer - 07 May 2012
UNITED NATIONS, New York&mdash;The Hellosmile Project, a joint campaign to prevent cervical cancer, initiated and led by TOKYO FM Broadcasting, and which includes UNFPA and other partners, will be officially launched in the United States this week. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
16.05.12: Not intended for U.S. and UK media - 48th Annual Meeting of the American Society of Clinical Oncology (ASCO):
Bayer to Present Data on Late-Stage Development Oncology Compounds at ASCO 2012First data from Phase III trial for regorafenib in gastrointestinal tumors (GIST) presented as Late-Breaking Abstract in Oral Abstract Session / Updated survival results from Phase III trial for Alpharadin (radium-223 chloride) in castration-resistant prostate cancer (CRPC) presented as Late-Breaking Abstract in Oral Abstract Sessionmehr ... (Source: Bayer IR Newsfeed: Events)
Ultraviolet radiation resistance-associated polyadenine deletions in human gastric cancer
In this study, the authors reported that 9.4% of gastric tumors were associated with UVRAG poly-A frameshift mutations, only in gastric tumors showing the MSI pattern. (Source: Human Pathology)
Advances in the pathology of penile carcinomas
Summary: The incidence of penile cancer varies from country to country, with the highest figures reported for countries in Africa, South America, and Asia and lowest in the United States and Europe. Causes of this variation are not clear, but they are thought to be related to human papillomavirus infection, smoking, lack of circumcision, chronic inflammation, and poor genital hygiene. Most penile tumors are squamous cell carcinomas, and a variegated spectrum of distinct morphologies is currently recognized. Each one of these subtypes has distinctive pathologic and clinical features. About half of penile carcinomas are usual squamous cell carcinomas, and the rest corresponds to verrucous, warty, basaloid, warty-basaloid, papillary, pseudohyperplastic, pseudoglandular, adenosquamous, sarcoma...
Researchers Link PFOA, PFOS To Marker For Liver Damage
RESEARCH TRIANGLE PARK, N.C. - The serum levels of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in participants in the C8 Health Project participants are positively correlated with a marker for liver cancer, researchers report in a study published in the May 2012 Environmental Health Perspectives. (Source: LexisNexis&#174; Mealey's&#8482; Emerging Toxic Torts Legal News)
Royal college criticises SHA for moving mental health funds
FINANCE: The president of the Royal College of Psychiatrists has said she is ?deeply concerned? by a strategic health authority?s decision to cut a mental health budget in favour of cancer spending. (Source: HSJ)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
Targeted therapy is effective, has few side effects, but larger trials needed, researchers say (Source: The Doctors Lounge - Health News)
Many Primary Care Docs Don't Know Long-Term Effects of Chemo: Survey
Experts stress that information needs to be passed on after cancer treatment ends (Source: Cancercompass News: Breast Cancer)
Two-Drug Combo May Be Safe for Melanoma Treatment
Preliminary research found reduced skin-lesion side effect (Source: Cancercompass News: Other Cancer)
Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
Targeted therapy is effective, has few side effects, but larger trials needed, researchers say (Source: Cancercompass News: Other Cancer)
Advanced Prostate Cancer Drug May Help at Earlier Stage
In study, one-third benefited from taking Zytiga plus hormone therapy for 6 months before surgery (Source: Cancercompass News: Other Cancer)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Children with cancer have complete responses in a COG phase 1 trial: Pills zero in on abnormal genes that drive specific cancers
A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma. (Source: ScienceDaily Headlines)
Chemo Before Surgery Clears Prostate Cancer
(MedPage Today) -- A third of men with localized, high-risk prostate cancer achieved pathologic complete response or near-complete response following neoadjuvant therapy with abiraterone and an LHRH agonist, results of a preliminary clinical study showed. (Source: MedPage Today Hematology/Oncology)
Zyprexa Reduces Nausea from Chemo
(MedPage Today) -- A well-known anti-psychotic drug can help cancer patients bear some of the side effects of chemotherapy, a researcher said. (Source: MedPage Today Gastroenterology)
Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells
CONCLUSIONSOur investigation demonstrates for the first time that PL induces rapid depletion of the AR in PC cells. As such, PL may afford novel opportunities for both prevention and treatment of prostatic malignancy. Prostate © 2012 Wiley Periodicals, Inc. (Source: The Prostate)
Pediatric Tumors Respond to Xalkori
(MedPage Today) -- The targeted agent crizotinib (Xalkori) appears to dramatically reduce the size of tumors in children with refractory cancers that appear driven by the anaplastic lymphoma kinase (ALK), researchers reported. (Source: MedPage Today Hematology/Oncology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
How prostate cancer patients cope: evaluation and refinement of the Prostate Cancer Patients? Coping Strategies Questionnaire
Conclusion: PCa patients? ability to respond effectively to the kinds of stressors they encounter appears to be dependent upon the specificity of the stressor itself, with more general responses being made to stressors that were less specific in their effects upon patients. Implications for assessment of PCa patients? ability to cope with the stress they experience, and methods of developing individualised coping strategies, are discussed. (Source: Journal of Men's Health)
Rockefeller hosts first Leon Levy Neuroscience Fellows Symposium
The first Leon Levy Neuroscience Fellows Symposium will be held at Rockefeller University on Wednesday, May 16. Levy Fellows from Rockefeller, Columbia and New York universities, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College will discuss their latest neuroscience research with current Leon Levy Fellows as well as their mentors, former fellows and principal investigators involved with the fellowship program. More &#187; (Source: The Rockefeller University Newswire)
Introduction: Therapeutic Cancer Vaccines
This issue of Seminars in Oncology is aimed at defining the current state of research, development, and clinical evaluation of therapeutic cancer vaccines. The various chapters review potential reasons for past failures, the US Food and Drug Administration (FDA) approval of Sipuleucel-T for prostate cancer therapy, promising randomized phase II and phase III results with several other therapeutic vaccines in different cancer types, and the broad range of cancer vaccines and vaccine strategies currently being evaluated in preclinical settings and in phase I and phase II trials. (Source: Seminars in Oncology)
Sipuleucel-T for the Treatment of Advanced Prostate Cancer
Sipuleucel-T is an autologous cellular immunotherapy designed to stimulate an immune response to prostate cancer that prolongs the overall survival of men with asymptomatic or minimally symptomatic metastatic castrate-resistant prostate cancer (CRPC). The clinical development program and key efficacy, safety, and immune response findings from the phase III studies are presented. The integration of sipuleucel-T into the treatment paradigm of advanced prostate cancer and future directions for research are discussed. (Source: Seminars in Oncology)
Lymphoma Vaccine Therapy: Next Steps After a Positive, Controlled Phase III Clinical Trial
Many of the efforts toward developing vaccines against human malignancies have been frustrated by the lack of identification of a tumor-specific antigen that would allow tumor cells to be distinguished from normal cells. Idiotypic determinants of the surface immunoglobulin (Ig) associated with a given patient's B-cell lymphoma are unique to that tumor, and can thus serve as a tumor-specific marker. When conjugated to the immune carrier keyhole limpet hemocyanin (KLH), vaccination with an idiotype protein vaccine has been able to improve length of freedom from disease relapse in patients with follicular lymphoma (FL) in a minimal residual disease (MRD) state after induction therapy, as demonstrated in a recent randomized, controlled phase III trial. In addition to predictive biomarker disco...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Vaccines for Melanoma and Renal Cell Carcinoma
The inherent immunogenicity of melanoma and renal cell carcinoma (RCC) has made these tumors a focus of considerable research in vaccine development. Recent data from murine studies of immunosurveillance have highlighted the importance of both innate and adaptive immune responses in shaping a tumor's inherent susceptibility to immune surveillance and immunotherapy. Melanoma has been a useful model for the identification of tumor-associated antigens and a number of putative renal cell antigens have been described more recently. These antigens have been targeted using a variety of vaccine strategies, including protein- and peptide-based vaccines, recombinant antigen-expressing vectors, and whole cell vaccine approaches. While evidence for clinical benefit has been disappointing to date, seve...
Whole Cell Vaccines?Past Progress and Future Strategies
Cancer vaccines have shown success in curing tumors in preclinical models. Accumulating evidence also supports their ability to induce immune responses in patients. In many cases, these responses correlate with improved clinical outcomes. However, cancer vaccines have not yet demonstrated their true potential in clinical trials. This is likely due to the difficulty in mounting a significant anti-tumor response in patients with advanced disease because of pre-existing tolerance mechanisms that are actively turning off immune recognition in cancer patients. This review will examine the recent progress being made in the design and implementation of whole cell cancer vaccines, one vaccine approach that simultaneously targets multiple tumor antigens to activate the immune response. These vaccin...
Dendritic/Tumor Fusion Cells as Cancer Vaccines
A promising cancer vaccine involves the fusion of dendritic cells (DCs) with tumor cells such that a broad array of tumor antigens are presented in the context of DC-mediated costimulation and stimulatory cytokines. In diverse animal models, vaccination with DC/tumor fusions results in protection from an otherwise lethal challenge of tumor cells and eradication of established disease. In phase I clinical studies, vaccination with DC/tumor fusions was well tolerated, and induced immunologic responses in the majority of patients and clinical responses in a subset. Vaccine efficacy may be blunted by the immunosuppressive milieu characteristic of patients with malignancy, including the increased presence of regulatory T cells, and inhibitory pathways such as the PD-1/PDL-1 pathway. A current f...
Clinical Evaluation of TRICOM Vector Therapeutic Cancer Vaccines
We have developed an ?off-the-shelf? vector-based vaccine platform containing transgenes for carcinoma-associated antigens and multiple costimulatory molecules (designated TRICOM). Two TRICOM platforms have been evaluated both preclinically and in clinical trials. PROSTVAC consists of rV, rF-PSA-TRICOM and is being used in prostate cancer therapy trials. PANVAC consists of rV, rF-CEA-MUC1-TRICOM; the expression of the two pan-carcinoma transgenes CEA and MUC-1 renders PANVAC vaccination applicable for therapeutic applications for a range of human carcinomas. Many new paradigms have emerged as a consequence of completed and ongoing TRICOM vaccine trials, including (1) clinical evidence of patient benefit may be delayed, because multiple vaccinations may be necessary to induce a sufficie...
Novel Recombinant Alphaviral and Adenoviral Vectors for Cancer Immunotherapy
Although cellular immunotherapy based on autolgous dendritic cells (DCs) targeting antigens expressed by metastatic cancer has demonstrated clinical efficacy, the logistical challenges in generating an individualized cell product create an imperative to develop alternatives to DC-based cancer vaccines. Particularly attractive alternatives include in situ delivery of antigen and activation signals to resident antigen-presenting cells (APCs), which can be achieved by novel fusion molecules targeting the mannose receptor and by recombinant viral vectors expressing the antigen of interest and capable of infecting DCs. A particular challenge in the use of viral vectors is the well-appreciated clinical obstacles to their efficacy, specifically vector-specific neutralizing immune responses. Becau...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Clinical Development of Listeria monocytogenes?Based Immunotherapies
Active immunotherapy targeting dendritic cells (DCs) has shown great promise in preclinical models and in human clinical trials for the treatment of malignant disease. Sipuleucel-T (Provenge, Dendreon, Seattle, WA), which consists of antigen-loaded dendritic cells (DCs), recently became the first targeted therapeutic cancer vaccine to be approved by the US Food and Drug Administration (FDA). However, ex vivo therapies such as Provenge have practical limitations and elicit an immune response with limited scope. By contrast, live-attenuated Listeria monocytogenes (Lm) naturally targets DCs in vivo and stimulates both innate and adaptive cellular immunity. Lm-based vaccines engineered to express cancer antigens have demonstrated striking efficacy in several animal models and have resulted in ...
The Tipping Point for Combination Therapy: Cancer Vaccines With Radiation, Chemotherapy, or Targeted Small Molecule Inhibitors
Therapeutic cancer vaccines are a unique treatment modality in that they initiate a dynamic process of activating the host immune system, which can then be exploited by concurrent or subsequent therapies. The addition of immunotherapy to standard-of-care cancer therapies has shown evidence of efficacy in preclinical models and in the clinical setting. This review examines the preclinical and clinical interactions between vaccine-mediated tumor-specific immune responses and local radiation, systemic chemotherapy, or select small molecule inhibitors, as well as the potential synergy between these modalities. (Source: Seminars in Oncology)
The Potential Beneficial Effects of Drugs on the Immune Response to Vaccination
Many immunotherapeutic agents in phase II cancer studies have given optimistic results, which were not confirmed in larger randomized studies. Here we explore the evidence that, contrary to previous opinion, many chemotherapeutic agents and other classes of drugs may enhance the response to therapeutic vaccines by reducing inflammation and/or by inhibiting regulatory T lymphocytes or myeloid-derived suppressor cells. In addition, some of these agents, such as the immunomodulatory drugs, may produce marked costimulatory activities as in the case of lenalidomide, which also has marked anti-inflammatory properties. With the first approval for a vaccine-based therapy for prostate cancer, we propose that many more vaccines will be able to achieve approval, especially when combined with the opti...
Strategies to Use Immune Modulators in Therapeutic Vaccines Against Cancer
Cancers so much resemble self that they prove difficult for the immune system to eliminate, and those that have already escaped natural immunosurveillance have gotten past the natural immune barriers to malignancy. A successful therapeutic cancer vaccine must overcome these escape mechanisms. Our laboratory has focused on a multistep ?push-pull? approach in which we combine strategies to overcome each of the mechanisms of escape. If tumor epitopes are insufficiently immunogenic, we increase their immunogenicity by epitope enhancement, improving their binding affinity to major histocompatibility complex (MHC) molecules. If the anti-tumor response is too weak or of the wrong phenotype, we use cytokines, costimulatory molecules, Toll-like receptor ligands, and other molecular adjuvants to...
Cancer Vaccines Targeting the Epithelial-Mesenchymal Transition: Tissue Distribution of Brachyury and Other Drivers of the Mesenchymal-Like Phenotype of Carcinomas
The epithelial-mesenchymal transition (EMT) is thought to be a critical step along the metastasis of carcinomas. In addition to gaining motility and invasiveness, tumor cells that undergo EMT also acquire increased resistance to many traditional cancer treatment modalities, including chemotherapy and radiation. As such, EMT has become an attractive, potentially targetable process for therapeutic interventions against tumor metastasis. The process of EMT is driven by a group of transcription factors designated as EMT transcription factors, such as Snail, Slug, Twist, and the recently identified T-box family member, Brachyury. In an attempt to determine which of these drivers of EMT is more amenable to targeted therapies and, in particular, T-cell?mediated immunotherapeutic approaches, we ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
DNA Repair Biomarkers Predict Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer
This very small study elucidates new biomarkers, the use of which may help stratify patients with esophageal cancer and lead to potential new targets for therapy. Abstract Purpose: The addition of neoadjuvant... (Source: OncologySTAT Journal Scans)
Diffuse Large B-Cell Lymphoma: Current Treatment Approaches
This article examines clinical and biological features of DLBCL patients with poor outcomes, and reviews recent studies addressing alternatives to standard front-line management strategies together with unresolved questions. (Source: Cancer Network)
The incidence of metastasis from cutaneous squamous cell carcinoma and the impact of its risk factors
ConclusionsWe show a 1.9?2.6% metastatic rate for cSCC with MCD, histologic differentiation, PNI, and certain anatomical sub?sites being independent risk factors for metastasis. A prospective study on our proposed risk stratification scheme based on these parameters may lead to identification of high?risk lesions that would benefit from more intensive treatment and/or routine post?operative follow?up. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Prostate-specific membrane antigen can promote in vivo osseous metastasis of prostate cancer cells in mice.
Authors: Liang-Yun Z, Xiao-Peng M, Kai-Yuan C, Sheng-Jie G, Shao-Peng Q PMID: 22584637 [PubMed - as supplied by publisher] (Source: Braz J Med Biol Res)
Prevalence of ER?-397 PvuII C/T, ER?-351 XbaI A/G and PGR PROGINS polymorphisms in Brazilian breast cancer-unaffected women.
Authors: Giacomazzi J, Aguiar E, Palmero EI, Schmidt AV, Skonieski G, Filho DD, Bock H, Saraiva-Pereira ML, Ewald IP, Schuler-Faccini L, Camey SA, Caleffi M, Giugliani R, Ashton-Prolla P PMID: 22584640 [PubMed - as supplied by publisher] (Source: Braz J Med Biol Res)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
SLU to break ground on $3 million bone marrow transplant center
Saint Louis University will break ground this week on an approximately $3 million, 9,000 square-foot outpatient bone marrow transplant center, according to Alex Lovshin, director of special projects at Saint Louis University Hospital. The center, the first outpatient bone marrow transplant center in the region, will be located within the Saint Louis University Cancer Center on the main hospital?s campus in a space previously used as an operating suite by Bethesda Health Group. The new center... (Source: bizjournals.com Health Care:Physician Practices headlines)
SLU Hospital to break ground on $3 million bone marrow transplant center
Saint Louis University Hospital will break ground this week on an approximately $3 million, 9,000-square-foot outpatient bone marrow transplant center, according to Alex Lovshin, director of special projects at Saint Louis University Hospital. The center, the first outpatient bone marrow transplant center in the region, will be located within the Saint Louis University Cancer Center on the main hospital?s campus in a space previously used as an operating suite by Bethesda Health Group. The new... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Nine new breast cancer risk genes: Landscape of cancer genes and mutational processes in breast cancer complicated
Researchers have described nine new genes that drive the development of breast cancer. This takes the tally of all genes associated with breast cancer development to 40. (Source: ScienceDaily Headlines)
Want to avoid erectile dysfunction following prostate cancer surgery? Find an experienced, gentle surgeon
A new study suggests that men undergoing robotic-assisted surgery for prostate cancer should look for a doctor who has performed at least 1,000 surgeries and who actively seeks to improve and enhance his surgical skills to help ensure a successful post-surgery recovery of erectile function. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Want to avoid ED following prostate surgery? Find an experienced, gentle surgeon
Prostate cancer is the most commonly diagnosed non-skin cancer in the U.S., and radical prostatectomy, the surgical removal of the prostate gland, remains the most popular therapeutic option, accounting for half of treatments. &nbsp; The procedure, however, is not without possible side effects, primarily erectile dysfunction and incontinence. But a good nerve-sparing surgical technique can lessen the likelihood of these undesirable outcomes, as can the skill and experience of the surgeon, according to a new UCLA study that focused on robotic-assisted prostate surgery. &nbsp; The study findings are published in the June 2012 print edition of the international peer-reviewed journal European Urology. &nbsp; Based on their research, the study authors recommend that men undergoing robotic-assis...
Consensus report on the radiological management of patients with gastrointestinal stromal tumours (GIST): recommendations of the German GIST Imaging Working Group.
Authors: Kalkmann J, Zeile M, Antoch G, Berger F, Diederich S, Dinter D, Fink C, Janka R, Stattaus J Abstract The aim was to reach consensus in imaging for staging and follow-up as well as for therapy response assessment in patients with gastrointestinal stromal tumours (GIST). The German GIST Imaging Working Group was formed by 9 radiologists engaged in assessing patients with GIST treated with targeted therapy. The following topics were discussed: indication and optimal acquisition techniques of computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET)/CT; tumour response assessment considering response criteria and measurement techniques on CT, MRI and PET/CT; result interpretation; staging interval and pitfalls. Contrast-enhanced CT is th...
Pheochromocytoma and paraganglioma: imaging characteristics.
Authors: Baez JC, Jagannathan JP, Krajewski K, O'Regan K, Zukotynski K, Kulke M, Ramaiya NH Abstract The accurate diagnosis of adult pheochromocytoma and paraganglioma necessitates a multidisciplinary approach that includes clinical history, biochemical testing, and multimodality imaging such as computed tomography, magnetic resonance imaging, and nuclear medicine studies. This review illustrates the different imaging characteristics of primary adult pheochromocytomas as well as both sympathetic and parasympathetic paragangliomas. The review also describes known genetic associations and shows common metastatic patterns. Knowledge of the diverse appearance of pheochromocytomas and paragangliomas can result in early initial diagnosis or detection of disease recurrence thereby affecti...
Imaging of sinonasal tumours.
This article presents the imaging findings in some of the most common benign and malignant sinonasal tumours, and the TNM classification and staging of sinonasal carcinomas. PMID: 22571851 [PubMed - in process] (Source: Cancer Imaging)
Imaging of complications of oncological therapy in the gastrointestinal system.
Authors: Viswanathan C, Bhosale P, Moorthy Ganeshan D, Truong MT, Silverman P, Balachandran A Abstract Treatment of cancer involves a multidisciplinary approach consisting of surgery, chemotherapy, molecular targeted therapy and radiation therapy. These therapies work on the tumor cells to result in cell stasis or cell death. The same mechanism can result in toxicity to the normal gastrointestinal tract. Radiation therapy can cause acute and chronic injury. The chronic injury results from involvement of the vascular supply of the gastrointestinal tract and by causing fibrosis. The purpose of this article is to describe the imaging of complications resulting from oncologic treatment in the gastrointestinal system. PMID: 22571819 [PubMed - in process] (Source: Cancer Imaging)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Sugar Makes You Stupid, But Omega-3s Will Smarten You Back Up
Though we may not have fully come to terms with it, in theory&nbsp;we know that high-fructose corn syrup (HFCS) is an adversary of health. Lots of work has been done looking at the effect of fructose on weight, liver function, diabetes risk, and even the growth of cancer cells. But not much has looked at the role of fructose in brain function, until now. Researchers have just reported that among the list of bodily ills that fructose contributes to, it may also "make you dumb.? Luckily, eating a diet rich in the healthy omega-3 fatty acids seems to counteract this phenomenon. (Source: Forbes.com Healthcare News)
JNM: PET/CT steers treatment for patients with esophageal cancer
18F-FDG PET/CT imaging impacted staging in 40 percent of patients newly diagnosed with esophageal cancer and management in 34 percent of patients, according to a study published online May 11 in the Journal of Nuclear Medicine. PET/CT may help physicians direct patients to appropriate treatment, which could translate into survival improvements for patients with locally advanced disease. (Source: Health Imaging News)
Alamance Regional files application for $60M expansion
Alamance Regional Medical Center released details Wednesday for a planned $60 million campus improvement project that includes expanding its cancer center and emergency department, the largest expansion since the hospital opened in 1995. The details follow the medical center filing a certificate of need application with state regulators on Tuesday for the project, which was first reported by The Business Journal last week. Because of the cost of the project, Alamance Regional must receive approval... (Source: bizjournals.com Health Care:Biotechnology headlines)
Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis
Carbohydrate modification of proteins adds complexity and diversity to the proteome. However, undesired carbohydrate modifications also occur in the form of glycation, resulting in diseases such as diabetes, Alzheimer&rsquo;s disease, autoimmune diseases, and cancer. The analysis of glycated proteins is challenging due to their complexity and variability. Numerous analytical techniques have been developed that require expensive specialised equipment and complex data analysis. In this chapter, we describe a simple electrophoresis-based method that enables users to detect, identify, and analyze these post-translational modifications. This new cost-effective methodology will aid the detection of unwanted glycation products in processed foods and may lead to new diagnostics and therapeutics fo...
Safer kidney cancer surgery under-used
An increasingly common and safer type of surgery for kidney cancer is not as likely to be used for older, sicker and poorer patients who are uninsured or rely on Medicare or Medicaid for their health care, according to a new study by researchers at Henry Ford Hospital.05/16/2012 (Source: Kidney Cancer Association)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Women Cope Better Than Men After Kidney Surgery
The results of the new study, based on population samples from throughout the U.S., will be presented this week at the American Urological Association’s Annual Meeting in Atlanta.05/16/2012 (Source: Kidney Cancer Association)
Kidney Cancer Linked to Gum Disease
There is a strong link between periodontal disease and kidney cancer, a recent research report in the prestigious journal, Lancet Oncology, confirmed that gum disease increases the risk of kidney cancer by around 50%.05/16/2012 (Source: Kidney Cancer Association)
Laxative-Free CT Colonography Finds High-Risk Polyps
A no-prep virtual colonoscopy appears to be as effective as a standard colonoscopy in detecting larger polyps that are more likely to become cancers. (Source: Diagnostic Imaging)
Rosetta Genomics Launches miRview Kidney
Rosetta Genomics Ltd. (ROSG), a leading developer and provider of microRNA-based molecular diagnostic tests, today announced the commercial launch of miRview® kidney, the Company's advanced microRNA assay that uses microRNA expression to classify the four most common kidney tumors: Clear Cell Renal Cell Carcinoma (RCC), Papillary RCC, Chromophobe RCC and Oncocytoma. miRview® kidney will be marketed in the U.S. by Rosetta Genomics' oncology sales team beginning this month. 05/16/2012 (Source: Kidney Cancer Association)
Investigating Potential Mechanisms of Obesity by Metabolomics
Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Metabolomics is an emerging analytical technique for systemic determination of metabolite profiles, which is useful for understanding the biochemical changes in obesity or related diseases both in individual organs and at the organism level. Increasingly, this technology has been applied to the study of obesity, complementing transcriptomics and/or proteomics analyses. Indeed, the alterations of metabolites in biofluids/tissues are direct indicators of variations in physiology or pathology. In this paper, we will examine the obesity-related alterations in significant metabolites that have been identified by metabolomics as well as their metabolic pat...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Make or break for cellular tissues
Models developed to study liquids are used to investigate the mechanics of cellular tissues, which could further our understanding of embryonic development and cancer. Scientists have demonstrated that the behavior of a thin layer of cells in contact with an unfavorable substrate is akin to that of thin fluid or elastic films. Understanding the mechanism by which a thin layer of cells splits into disjointed patches, thus breaking the layer's structural integrity, bears great significance because the human tissue, or epithelium, covering organs can only fulfill its role if there are no holes or gaps between the cells. (Source: ScienceDaily Headlines)
UNFPA, Partners, to Launch new Hellosmile Campaign to Help Prevent Cervical Cancer - 07 May 2012
UNITED NATIONS, New York&mdash;The Hellosmile Project, a joint campaign to prevent cervical cancer, initiated and led by TOKYO FM Broadcasting, and which includes UNFPA and other partners, will be officially launched in the United States this week. (Source: UNFPA News)
Mind, Body and Cancer
PHOENIX, May 16, 2012 (GLOBE NEWSWIRE) -- When it comes to cancer, there are obvious mind-body links. Stress, pessimism and other emotional factors have been proven to play a role, increasing the risk of cancer, metastasis and early mortality. This is a double-whammy for cancer patients, who must overcome anxiety from the moment they are diagnosed. In particular, stress has been shown to depress the immune system, increase inflammation and affect our bodies on the molecular level, even damaging DNA. (Source: Medical News (via PRIMEZONE))
Rinsability of Orthophthalaldehyde from Endoscopes
We examined this possibility by means of a zone-of-inhibition test, and also a test to extract residues of orthophthalaldehyde with acetonitrile, from sections of endoscope insertion tube materials, to measure the presence of alkaline glutaraldehyde, or glutaraldehyde plus 20&#37; w/w isopropanol, or ortho-phthalaldehyde that remained on the endoscope materials after exposure to these disinfectants followed by a series of rinses in water, or by aeration overnight. Zones of any size indicated the disinfectant had not been rinsed away from the endoscope material. There were no zones of inhibition surrounding endoscope materials soaked in glutaraldehyde or glutaraldehyde plus isopropanol after three serial water rinses according to manufacturers&#39; rinsing directions. The endoscope material...
Nursing in Practice Weekly Quiz - May 16th
This week we quiz you on breast cancer and measles and more. read more (Source: Nursing in Practice)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
'Nerve bypass' restores movement in man's paralysed arm
Conclusion This case report represents the positive experience of a paralysed 71-year-old man who has been granted some manual control after a serious spinal injury to his neck. Before surgery, he could only make minimal arm movements controlled by the nerves above his injury site, but no lifting or fine hand movements as they are controlled by nerves joined lower down the spine, below the site of his injury. While the nerve transfer technique given to this patient is not new, its application is not widespread and the authors say this is the first time it has been used to successfully rewire the nerves supplying a hand. Furthermore, these gains occurred after surgery that was carried out 23 months after the injury was sustained. This suggests that surgery does not have to be performed imme...
Summer Skin Care and Cancer Prevention Important at Every Age
The CareGiver Partnership chooses May, Skin Cancer Detection and Prevention Month, to remind readers rates of skin cancer are highest among people in their 80s, which is why prevention and early...(PRWeb May 16, 2012)Read the full story at http://www.prweb.com/releases/2012/5/prweb9506190.htm (Source: PRWeb: Medical Pharmaceuticals)
Molecular testing in colorectal cancer: diagnosis of lynch syndrome and personalized cancer medicine.
Authors: Shi C, Washington K Abstract Currently, molecular testing in colorectal cancer (CRC) is aimed at detecting Lynch syndrome and predicting response to anti-epidermal growth factor receptor (EGFR) therapies. However, CRC is a complex disease, with at least 3 molecular pathways of carcinogenesis. The importance of the EGFR signaling pathway in colorectal carcinogenesis is underscored by the availability of anti-EGFR monoclonal antibodies for the treatment of some metastatic CRCs. Potentially, mutations in any of the genes in the EGFR signaling pathway may be associated with prognosis and may predict response to anti-EGFR or other targeted therapies. Although not currently the standard of care, molecular testing of CRCs is expanding to include mutational analysis of the genes i...
A search for reliable molecular markers of prognosis in prostate cancer: a study of 240 cases.
Authors: Tradonsky A, Rubin T, Beck R, Ring B, Seitz R, Mair S Abstract Most prostate cancers are treated, although more than 80% remain clinically insignificant and fewer than 3% are fatal. This retrospective study of 240 radical prostatectomy cases with comprehensive follow-up was a search for reliable markers of prostate cancer prognosis evaluable on biopsy specimens to enable minimization of unnecessary treatment, morbidity, and costs. Representative cancer and benign tissue from each prostatectomy specimen was made into tissue microarrays and stained with antibodies targeting 20 gene sequences. Traditional clinical and pathologic prognosticators and the 20 antibody stains were correlated with patient outcomes. By univariable analysis 4 of 20 antibodies (STMN1/stathmin 1, CYP4Z...
Tissue-Sparing Application of the Newly Proposed IASLC/ATS/ERS Classification of Adenocarcinoma of the Lung Shows Practical Diagnostic and Prognostic Impact.
Authors: Sterlacci W, Savic S, Schmid T, Oberaigner W, Auberger J, Fiegl M, Tzankov A Abstract The histologic subtype of non-small cell lung cancer (NSCLC) determines treatment strategies and the need for genetic analyses. Since most NSCLC are diagnosed on small biopsy or cytologic specimens, an accurate but tissue-sparing approach is necessary. To date, consensus for a general diagnostic algorithm is lacking. To test the diagnostic and clinical relevance of the recently published multidisciplinary guidelines by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society, we examined 371 surgically resected NSCLCs brought into tissue microarray format. The antibody panel thyroid transcription factor-1 (TTF-1), p63, cytoker...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
The dynamics of death in prostate cancer.
In this study, hazard functions were derived for prostate cancer by using survival data on large numbers of patients with prostate cancer with data in the Surveillance, Epidemiology and End Results (SEER) database. The results demonstrate a form of prostate cancer that rapidly evolves to cause death within 5 years, and this form of tumor is only partly identified by routine prognostic variables such as serum prostate-specific antigen (PSA) level, histologic grade, and quantity of tumor. The results also validate the presence of a reservoir of nonfatal prostate cancers that have increased rapidly during the PSA era, and they demonstrate that the incidence of fatal prostate cancers has declined. PMID: 22586055 [PubMed - in process] (Source: American Journal of Clinical Pathology)
LMX1A as a Prognostic Marker in Ovarian Mucinous Cystadenocarcinoma.
This study aimed to evaluate the relationship of LMX1A and osteopontin (OPN) expression with clinicopathologic parameters for the 4 most common ovarian surface epithelial carcinomas. Both biomarkers were investigated immunohistochemically using tissue microarrays of 249 specimens including 91 serous cystadenocarcinomas, 56 mucinous cystadenocarcinomas, 64 endometrioid adenocarcinomas, 26 clear cell carcinomas, and 12 normal ovarian tissues. All 4 carcinomas showed significant expression of LMX1A and OPN. In addition, higher immunostaining scores and percentage of cells stained for LMX1A in mucinous cystadenocarcinomas correlated with T stage, American Joint Committee on Cancer clinical stage, poorer tumor differentiation, and poorer survival rate. In serous cystadenocarcinoma, higher perce...
Ectopic Expression of TIM-3 in Lung Cancers: A Potential Independent Prognostic Factor for Patients With NSCLC.
Authors: Zhuang X, Zhang X, Xia X, Zhang C, Liang X, Gao L, Zhang X, Ma C Abstract T-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3) is a membrane protein expressed in various kinds of immune cells and plays a pivotal role in immune regulation. Recently, TIM-3 was reported to be expressed aberrantly in melanoma cells, contributing to the low adhesion ability of tumor cells and promoting the survival of melanoma cells. We investigated TIM-3 expression in non-small cell lung cancers (NSCLCs), and further analyzed whether the aberrant expression of TIM-3 is related to the prognosis for patients with lung cancer. Tumor tissue samples from 30 patients with NSCLC were involved. Results of immunohistochemical analysis showed that TIM-3 stained positive on tumor cells...
In Clinical Trials, Breath Test for Lung Cancer Shows Promise for Earlier Detection
Pathologists may do fewer lung biopsies should non-invasive breath testing technology make it into clinical practice Here?s a medical laboratory test for diagnosing cancer that has the potential to score two runs with one swing of the bat. First, researchers have completed the first clinical trial of a non-invasive cancer test that utilizes a breath [...] (Source: Dark Daily)
Abiraterone reconsidered by NICE
Prostate cancer drug was recommended in draft guidance after Janssen offered a discounted, NHS price (Source: Pharmacy Europe)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
South Africa: UCKG's Women in Action Joins the Union for International Cancer Control to Help Fight Cancer
[Biz-Community] Women in Action (WiA), a group of pastors' wives from the Universal Church of the Kingdom of God (UCKG), is proud and honoured to announce its membership of the Union for International Cancer Control (UICC). (Source: AllAfrica News: Health and Medicine)
Prostate cancer drug Abiraterone set for approval in England and Wales but not Scotland
Abiraterone, marketed as Zytiga, should be given to patients in England and Wales, after a U-turn by the NHS rationing body. It has already been turned down in Scotland. (Source: the Mail online | Health)
Blacks, Hispanics Have Higher Colon Polyp Risk Than Previously Thought
Title: Blacks, Hispanics Have Higher Colon Polyp Risk Than Previously ThoughtCategory: Health NewsCreated: 5/15/2012 6:05:00 PMLast Editorial Review: 5/16/2012 12:00:00 AM (Source: MedicineNet Cancer General)
Linking EHRs to Cancer Registries Good in Theory, But Difficult in Practice, ASCO Says
The American Society of Clinical Oncology is questioning whether electronic health records are ready to meet a proposed meaningful use option that would have EHRs communicating with cancer registries,... (Source: OncologySTAT Latest News)
Fatty Acids in Fish May Lower Liver Cancer Risk
The consumption of fish rich in n-3 polyunsaturated fatty acids was inversely related to the risk of developing hepatocellular carcinoma in a population-based study of Japanese adults, Dr. Norie Sawada... (Source: OncologySTAT Latest News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Biologics for RA Do Not Increase Solid Cancer Risk
GLASGOW (EGMN) - Biologic treatment for rheumatoid arthritis does not increase the overall risk of solid cancers beyond that of more traditional, nonbiologic drugs, according to long-awaited data from... (Source: OncologySTAT Latest News)
Quality of life aids lung cancer prognosis
Self-reported quality of life at the time of lung cancer diagnosis has a significant impact on patients? survival, show US study results. (Source: MedWire News - Oncology)
Epidemiology of pancreatic cancer and the role of family history
AbstractPancreatic cancer is a lethal disease for which only a small number of risk factors have been identified. In addition to older age, male gender, and black race, risk factors include smoking, obesity, long?standing diabetes and pancreatitis, and heavy alcohol use; allergies such as hay fever are related to lowered risk. Several genetic syndromes increase risk of pancreatic cancer. Work on more common genetic variants promises to reveal more potentially important genetic associations. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Accuracy of concurrent visual and cytology screening in detecting cervical cancer precursors in rural India
We describe the performance of VIA, VILI and cytology, carried out in a multinational project called ?Screening Technologies to Advance Rapid Testing? in 5,519 women aged 30?49 years, in detecting cervical intraepithelial neoplasia (CIN). VIA, VILI and cytology were positive in 16.9%, 15.6% and 6.1% women, respectively. We found 57 cases of CIN2, 55 of CIN3 and 12 of cervical cancer; 90% of CIN3 and 43% CIN2 cases were positive for p16 over?expression and high?risk HPV infection, indicating a high validity of histological diagnosis. The sensitivity of VIA, VILI and cytology to detect high?grade CIN were 64.5%, 64.5% and 67.7%, respectively; specificities were 84.2%, 85.5% and 95.4%. A high proportion of p16 positive CIN 3 (93.8%) and 2 (76.9%) were positive on cytology compared...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma
In this study, we report a 13?year?old boy who was diagnosed with a plexiform neurofibroma, without other NF1 diagnostic criteria. The tumor was partially resected and analyzed using different techniques: karyotyping, fluorescence in situ hybridization (FISH), and microarray comparative genomic hybridization (aCGH). Tumor Schwann cell culture and subsequent karyotyping showed a rearrangement involving chromosomes 1 and 17, namely an insertion of chromosomal bands 1p36?35 at 17q11.2. FISH demonstrated that the insertion interrupted the NF1 gene. In addition, a deletion was detected affecting the other NF1 allele. Whole?genome aCGH analysis of the resected tumor confirmed the presence of an 8.28 Mb deletion including the NF1 gene locus in ?15?20% of tumor cells. We conclude that ...
There's a Time and a Place for MYCN
Timothy N. Phoenix, Richard J. Gilbertson. Brain tumors display extensive diversity. In this issue of Cancer Cell, Swartling et al. provide evidence that the temporal and spatial transcriptional programs in neural stem cells underli.... (Source: Cancer Cell)
What a Difference a Phosphate Makes: Life or Death Decided by a Single Amino Acid in MDM2
Yao-Cheng Li, Geoffrey M. Wahl. In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critic.... (Source: Cancer Cell)
SMIP-016 in Action: CD37 as a Death Receptor
Lei Jin, John C. Cambier. CD37 is a tetraspannin that triggers cell death and is a potential therapeutic target in cancers. In this issue of Cancer Cell, Lapalombella et al. show that CD37 is tyrosine phosphorylated.... (Source: Cancer Cell)
Opening a New GATAway for Treating KRAS-Driven Lung Tumors
Mariano Barbacid. In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmaco.... (Source: Cancer Cell)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC
Fredrik J. Swartling, Vasil Savov, Anders I. Persson, Justin Chen, Christopher S. Hackett, Paul A. Northcott, Matthew R. Grimmer, Jasmine Lau, Louis Chesler, Arie Perry, Joanna J. Phillips, Michael D. Taylor, William A. Weiss. The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or m.... (Source: Cancer Cell)
Allele-Specific p53 Mutant Reactivation
Xin Yu, Alexei Vazquez, Arnold J. Levine, Darren R. Carpizo. Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we identified two compounds from the th.... (Source: Cancer Cell)
Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer
Keli Xu, Jerry Usary, Philaretos C. Kousis, Aleix Prat, Dong-Yu Wang, Jessica R. Adams, Wei Wang, Amanda J. Loch, Tao Deng, Wei Zhao, Robert Darrell Cardiff, Keejung Yoon, Nicholas Gaiano, Vicki Ling, Joseph Beyene, Eldad Zacksenhaus, Tom Gridley, Wey L. Leong, Cynthia J. Guidos, Charles M. Perou, Sean E. Egan. Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch receptor signaling promotes luminal cell fate specification in the mammary gland, while suppressing stem cell se.... (Source: Cancer Cell)
S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites
Jiehui Deng, Yong Liu, Heehyoung Lee, Andreas Herrmann, Wang Zhang, Chunyan Zhang, Shudan Shen, Saul J. Priceman, Maciej Kujawski, Sumanta K. Pal, Andrew Raubitschek, Dave S.B. Hoon, Stephen Forman, Robert A. Figlin, Jie Liu, Richard Jove, Hua Yu. Recent studies underscore the importance of myeloid cells in rendering distant organs hospitable for disseminating tumor cells to colonize. However, what enables myeloid cells to have an apparentl.... (Source: Cancer Cell)
DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival
Daniel D. De Carvalho, Shikhar Sharma, Jueng Soo You, Sheng-Fang Su, Phillippa C. Taberlay, Theresa K. Kelly, Xiaojing Yang, Gangning Liang, Peter A. Jones. Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant transformation. Whether cancer cells are dependent on these abnormal epigenetic modifications remains elus.... (Source: Cancer Cell)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice
Hugh S. Gannon, Bruce A. Woda, Stephen N. Jones. DNA damage induced by ionizing radiation activates the ATM kinase, which subsequently stabilizes and activates the p53 tumor suppressor protein. Although phosphorylation of p53 by ATM was found pr.... (Source: Cancer Cell)
In Vivo Imaging of Tumor-Propagating Cells, Regional Tumor Heterogeneity, and Dynamic Cell Movements in Embryonal Rhabdomyosarcoma
Myron S. Ignatius, Eleanor Chen, Natalie M. Elpek, Adam Z. Fuller, Inês M. Tenente, Ryan Clagg, Sali Liu, Jessica S. Blackburn, Corinne M. Linardic, Andrew E. Rosenberg, Petur G. Nielsen, Thorsten R. Mempel, David M. Langenau. Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. Here, we show that ERMS-propagating potential is confined to myf5+ cells and can be visualized in live, fluor.... (Source: Cancer Cell)
Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals
Rosa Lapalombella, Yuh-Ying Yeh, Liwen Wang, Asha Ramanunni, Sarwish Rafiq, Shruti Jha, Justin Staubli, David M. Lucas, Rajeswaran Mani, Sarah E.M. Herman, Amy J. Johnson, Arletta Lozanski, Leslie Andritsos, Jeffrey Jones, Joseph M. Flynn, Brian Lannutti, Peter Thompson, Paul Algate, Scott Stromatt, David Jarjoura, Xiaokui Mo, Dasheng Wang, Ching-Shih Chen, Gerard Lozanski, Nyla A. Heerema, Susheela Tridandapani, Michael A. Freitas, Natarajan Muthusamy, John C. Byrd. Tetraspanins are commonly believed to act only as ?molecular facilitators,? with no direct role in signal transduction. We herein demonstrate that upon ligation, CD37, a tetraspanin molecule expre.... (Source: Cancer Cell)
SnapShot: Glioblastoma Multiforme
Svetlana Kotliarova, Howard A. Fine. (Source: Cancer Cell)
Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival
Conclusions:? Our results suggest that MTDH protein may be a valuable marker of bladder cancer progression. MTDH expression is associated with poor overall survival in patients with bladder cancer. (Source: Asia-Pacific Journal of Clinical Oncology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Genetic Testing in Gastrointestinal Cancers: A Case-Based Approach
In this article, we use a case-based approach to focus on the hereditary aspects of the most common GI cancers, including pancreatic, gastric, and colon cancer. (Source: Cancer Network)
TIM3 gene polymorphisms in patients with chronic hepatitis B virus infection: impact on disease susceptibility and hepatocellular carcinoma traits
This study explored the polymorphisms of TIM3 gene in 535 patients with HBV?related liver diseases including 213 chronic hepatitis, 178 cirrhosis and 144 HCC, 72 HBV infection resolvers and 182 healthy controls and analyzed the effects of these polymorphisms on the disease susceptibility and HCC traits. TIM3?1541C/T, ?1516G/T, ?882C/T, ?574G/T and +4259T/G polymorphisms were genotyped using polymerase chain reaction?restriction fragment length polymorphism. Of the five polymorphisms genotyped, the allele T?containing genotypes (GT + TT), allele T and allele T?containing haplotype (CTCGT) of ?1516G/T polymorphism were more frequent in HBV patients than in controls [P = 0.005, odds ratio (OR) = 2.300, 95% confidence interval (CI): 1.294?4.088; P = 0.004, OR = 2.266, 95% C...
Baking soda, cancer and fungus
(NaturalNews)The cancer industry is closing in on baking soda and beginning to do research in earnest about sodium bicarbonate and how it is a primary tool in the treatment of fungus. Cancer is a fungus, can be caused by a fungus, or is accompanied by late-stage fungal infections... (Source: NaturalNews.com)
Roche will report new data on important progress for people with advanced cancers at ASCO 2012
Roche today announced that the company will present important new data from studies of several of its cancer medicines at the 48th Annual Meeting of the American Society of Clinical Oncology (ASCO), June 1 to 5, 2012, in Chicago. At the meeting, data on Roche&#8217;s late-stage investigational and approved cancer medicines will be communicated in sessions that include 30 oral presentations. (Source: Roche Media News)
Efficient Minimax Estimation of a Class of High-Dimensional Sparse Precision Matrices
Estimation of the covariance matrix and its inverse, the precision matrix, in high-dimensional situations is of great interest in many applications. In this paper, we focus on the estimation of a class of sparse precision matrices which are assumed to be approximately inversely closed for the case that the dimensionality $p$ can be much larger than the sample size $n$, which is fundamentally different from the classical case that $p &lt; n$. Different in nature from state-of-the-art methods that are based on penalized likelihood maximization or constrained error minimization, based on the truncated Neumann series representation, we propose a computationally efficient precision matrix estimator that has a computational complexity of $O(p^{3})$. We prove that the proposed estimator is consis...
Well: Phys Ed: Cancer Survivors Who Exercise Live Longer
Even moderate activity like taking a walk may improve cancer survivors' long-term prognosis, according to new research showing that regular exercise can lower survivors' risk of premature death, not only from cancer but from any cause. (Source: NYT)
Public awareness and cervical cancer screening
(Source: Cytopathology)
Segmentation of Corpus Callosum using diffusion tensor imaging: validation in patients with glioblastoma
Conclusions: The proposed method and similarity measure segment corpus callosum by propagating a hyper-surface inside the structure (resulting in high sensitivity), without penetrating into neighboring fiber bundles (resulting in high specificity). (Source: BMC Medical Imaging - Latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
Chest Radiography as a Method of Screening for Occult Cancer in Patients With Idiopathic Deep Vein Thrombosis
The occurrence of neoplasms in patients with idiopathic deep vein thrombosis (DVT) may result in a significant reduction in survival rates. The aim of our study was to assess the use of chest X-rays (CXRs) as a screening method of intrathoracic neoplasms in patients who with idiopathic DVT. In observational, cross-sectional study, the medical records of 99 patients with idiopathic DVT, who were submitted to CXR (during the hospital stay or within 30 days after discharge), were investigated. Of these patients, 15.1% had images suggestive of thoracic neoplasias (single or multiple pulmonary nodules and mediastinal widening). Neoplasms were diagnosed in 4 patients in the follow-up with CXR. The CXR is an option of early screening for thoracic neoplasms and other nonmalignant diseases in patie...
Metabolic Syndrome and Colorectal Cancer: The Protective Role of Mediterranean Diet--A Case-Control Study
The effect of Mediterranean diet on colorectal cancer, in the presence of the metabolic syndrome, was evaluated in 250 patients with first developed cancer (63 &plusmn; 12 years, 59% males) and 250 age&ndash;gender-matched controls. Adherence to the Mediterranean diet was evaluated with the modified-MedDietScore (theoretical range 0-75), while assessment of the metabolic syndrome (MetS) was based on the third Adult Treatment Panel ([ATP III] National Cholesterol Education Program) criteria. Presence of MetS (1.66, 95% confidence interval [CI] 1.02, 2.69), age (4.25, 95% CI 2.33, 7.77), smoking (1.85, 95% CI 1.27, 2.70), and family history of colorectal cancer (3.37, 95% CI 1.69, 6.75) had a detrimental effect, whereas adherence to the Mediterranean diet (0.88, 95% CI 0.84, 0.92) and body m...
NICE makes U-turn in favour of abiraterone
NICE reverses Zytiga decision as manufacturer amends patient access schemeRelated items from OnMedicaGuideline promises to transform cancer care for patientsAlso in the pressNICE recommends Herceptin for gastric cancerCharities condemn ?no? decision on prostate drugNICE takes U-turn on dementia drugs (Source: OnMedica Latest News)
Also in the press
Cancer and alzheimer's treatments; doctors' strike; cancer death rates fall; and private hopsitals Related items from OnMedicaCharity calls for better prevention and diagnosis for bowel cancerPrivate firm takes over NHS hospitalPrivate firm chosen to run community servicesDoctors dub NHS pension plans: ?damaging? and ?unfair?Doctors balloted on industrial action over pensions (Source: OnMedica Latest News)
The importance of intraoperative fluid balance for the prevention of postoperative acute exacerbation of idiopathic pulmonary fibrosis after pulmonary resection for primary lung cancer [THORACIC]
CONCLUSIONS To prevent PAE of IPF, intraoperative management that minimizes intravenous fluid administration is essential. Moreover, caution is particularly important in patients with preoperative evidence of inflammation. (Source: European Journal of Cardio-Thoracic Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Have a look at <a href="http://www.theoncologydaily.com">The Cancer and Oncology Daily</a>, the new cancer portal with all the latest cancer news and research powered by MedWorm, updated daily.</p></div>
High expression of octamer-binding transcription factor 4A, prominin-1 and aldehyde dehydrogenase strongly indicates involvement in the initiation of lung adenocarcinoma resulting in shorter disease-free intervals [BASIC SCIENCE]
CONCLUSIONS Our study reveals that CSC-associated markers: OCT4A, CD133 and ALDH are involved in the initial phase of carcinogenesis of LAC, and can be used as predictors of early stage LAC and poor disease-free intervals. In addition, this work validates the relevance of the CSC hypothesis in LAC. (Source: European Journal of Cardio-Thoracic Surgery)
Effects of low-dose human atrial natriuretic peptide for preventing post-operative cardiopulmonary complications in elderly patients undergoing pulmonary resection for lung cancer [THORACIC]
CONCLUSIONS Continuous infusion of low-dose hANP during lung cancer surgery had a prophylactic effect on post-operative cardiopulmonary complications in elderly lung cancer patients. (Trial registration number: JPRN-UMIN000003631). (Source: European Journal of Cardio-Thoracic Surgery)
The value of pleural lavage cytology examined during surgery for primary lung cancer [THORACIC]
CONCLUSIONS Examining PLC in clinical practice is useful for detecting occult pleural dissemination before the appearance of a malignant pleural effusion. Evidence of positive findings should be treated as supplemental information to the precise diagnosis of TNM staging. Scoring positive PLC findings as PL3 (=T3) was appropriate. (Source: European Journal of Cardio-Thoracic Surgery)
Mediastinal lymph node dissection in early-stage non-small cell lung cancer: totally thoracoscopic vs thoracotomy [THORACIC]
CONCLUSIONS For patients undergoing thoracoscopic lobectomy or segmentectomy for clinical early-stage NSCLC, the quality of mediastinal LND is equivalent to that performed by thoracotomy. (Source: European Journal of Cardio-Thoracic Surgery)